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  • Title: [Effect of ribamidil on the reproduction of the herpes simplex virus in a CV1 cell culture].
    Author: Linitskaia GL, Kroĭcha IuG, Galegov GA.
    Journal: Vopr Virusol; 1983; 28(6):673-5. PubMed ID: 6322451.
    Abstract:
    Cytotoxic properties and antiviral activity of abnormal nucleoside ribamidile were studied on the model of herpes simplex virus type 1 in CV1, continuous cell culture. The drug produced no cytotoxic effect even in concentrations of 500 and 250 micrograms/ml but had a marked capacity to inhibit herpes simplex virus reproduction in this system in concentrations of 125 and 62.5 micrograms/ml. Antiviral effect of ribamidile was enhanced by its combined use with 5'-deoxy-5'-fluorothymidine.
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