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  • Title: [Vaccinating properties of the Kekava 55 strain of attenuated Marek's disease virus].
    Author: Iakovleva LS, Mazurenko NP.
    Journal: Vopr Virusol; 1983; 28(6):689-93. PubMed ID: 6322454.
    Abstract:
    Two attenuated strains of oncogenic herpes virus, Marek's disease virus, were obtained: one by cultivation in chick fibroblast cultures at 37 degrees C, the other at 41 degrees C, i. e. at chicken body temperature. Both attenuated strains throughout a large number of passages retain high vaccination efficacy, on the average 76% and 77.3%, respectively. The virus attenuated at 41 degrees C is superior to that attenuated at 37 degrees C in higher reproduction rate in vitro and, possibly, in a greater range of passages during which good vaccinating properties are retained. Unlike turkey herpes virus, both attenuated strains reduce the spread of the infection markedly.
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