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  • Title: [Autoimmunity in patients with bronchogenic carcinomas: occurrence of antibodies against nuclear antigens, chromosomes and ds-deoxyribonucleic acid].
    Author: Dellen H, Seemayer NH.
    Journal: Zentralbl Bakteriol Mikrobiol Hyg B; 1983 Sep; 177(6):451-68. PubMed ID: 6322478.
    Abstract:
    We report about occurrence of antinuclear antibodies (ANA), antibodies against chromosomes and ds-DNA in sera from patients with bronchogenic carcinomas of various histology. For detection of antibodies we used the method of indirect immunofluorescence. As antigenic substrates served cell cultures of kidneys from Cerc. aeth. and HeLa-cells. We found antinuclear antibodies in 79 sera from 133 sera of patients with bronchogenic carcinomas employing kidney cell cultures. The antinuclear antibodies of the 79 positive sera belong in 68 cases to immunglobuline class of IgG, in 15 cases to the class of IgM. Using positive sera we observed 4 patterns of nuclear fluorescence: homogeneous (diffuse), peripheral or rim-pattern, speckled and nucleolar. 32 of the 79 positive tumor sera contained also antibodies against the mitotic apparatus of kidney cell cultures. Applying HeLa cells as an antigenic substrate 62 of the 133 analyzed tumor sera showed antinuclear antibodies, in 16 of them we detected also antibodies against the mitotic apparatus of these cells. These 16 sera contained in 9 cases antichromocomal antibodies, in 7 cases antiperichromosomal antibodies when using spread chromosomes of HeLa-cells as a substrate. Antibodies directed against ds-DNA were seen in 39 of the 133 tumor sera utilizing hemoflagellate Crithidia luciliae as an antigenic substrate. We want to emphasize that about half of the patients containing antinuclear antibodies in their sera showed at the same time antibodies against ds-DNA and in one third of the cases we could demonstrate also antimitotic antibodies. Furthermore, we discuss significance of autoimmune phenomena in tumor diseases, especially in bronchogenic carcinomas.
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