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  • Title: [Carcinoma in the operated stomach of the rat--a tumor model].
    Author: Dittrich S, Theuring F, Heinrich P, Wolter FH.
    Journal: Arch Geschwulstforsch; 1984; 54(1):33-40. PubMed ID: 6322721.
    Abstract:
    85 Wistar rats were operated on stomach. Carcinomas in the operated stomach were seen without additional application of a carcinogen 31 and 40 weeks after gastric surgery. Histologically adeno and scirrhous carcinomas were diagnosed. Metastases were observed in rats with gastric cancer. Dysplastic changes and chronic inflammatory reactions of gastric mucosa were seen. The enterogastric reflux is an aetiopathogenic factor in carcinogenesis. Because of reproductivity, high tumor rate, no additional application of a carcinogen and the little operative extent, this experimental model offers to be a model of carcinogenesis in stomach.
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