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  • Title: Interaction of purines and related compounds with photoaffinity-labelled benzodiazepine receptors in rat brain membranes.
    Author: Davies LP, Chow SC, Johnston GA.
    Journal: Eur J Pharmacol; 1984 Jan 27; 97(3-4):325-9. PubMed ID: 6323194.
    Abstract:
    The interaction of purine-receptor agonists and antagonists with [3H]Ro15-1788 binding sites in rat brain membranes was examined before and after UV-photoaffinity labelling of a proportion of the sites with flunitrazepam. Whereas photoaffinity labelling of the receptors reduced benzodiazepine agonist affinity but not benzodiazepine antagonist affinity, the IC50S of adenosine-receptor agonists, partial agonists and antagonists were unaltered by the conformational changes in the benzodiazepine receptors which are thought to be induced by the photolabelling process. The affinity of dipyridamole, a potent adenosine uptake blocker and potent displacer of [3H]diazepam binding, was drastically reduced by photolabelling.
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