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  • Title: Antihypertensive profile of the angiotensin-converting enzyme inhibitors CI-906 and CI-907.
    Author: Ryan MJ, Boucher DM, Cohen DM, Olszewski BJ, Singer RM, Smith RD, Kaplan HR.
    Journal: Fed Proc; 1984 Apr; 43(5):1330-2. PubMed ID: 6323224.
    Abstract:
    CI-906 and CI-907, new orally active nonsulfhydryl angiotensin-converting enzyme inhibitors, were examined for antihypertensive effects in unanesthetized hypertensive rats and dogs. In two-kidney, one-clip Goldblatt hypertensive rats, single oral daily doses (0.03-30 mg/kg) produced dose-dependent decreases in blood pressure; a single 3 mg/kg oral dose lowered blood pressure to normotensive levels. In spontaneously hypertensive rats, 30 mg/(kg X day) orally administered for 5 consecutive days achieved the same blood pressure decrease as that obtained on the first day in the renal hypertensive rats. In diuretic-pretreated renal hypertensive dogs, a 10 mg/kg oral dose decreased blood pressure by 25%. No adverse side effects were observed with CI-906 and CI-907 in any of the conscious animals. These studies indicate that CI-906 and CI-907 are potent, orally active antihypertensive agents without any apparent limiting side effects.
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