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  • Title: Human natural cytotoxic cell activity: enhancement by leukotrienes (LT) A4, B4 and D4, but not by stereoisomers of LTB4 or HETES.
    Author: Rola-Pleszczynski M, Gagnon L, Rudzinska M, Borgeat P, Sirois P.
    Journal: Prostaglandins Leukot Med; 1984 Jan; 13(1):113-7. PubMed ID: 6324237.
    Abstract:
    Natural cytotoxic activity of human lymphocytes was significantly enhanced by incubation with LTA4, LTB4 or LTD4. In contrast, stereoisomers of LTB4 as well as 5-HETE and 12-HETE were not active. These findings suggest that leukotrienes may play an important role in host defense mechanisms.
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