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  • Title: Complex action of antidepressant treatment on central adrenergic system: possible relevance to clinical effects.
    Author: Vetulani J.
    Journal: Pharmacopsychiatry; 1984 Jan; 17(1):16-21. PubMed ID: 6324248.
    Abstract:
    Chronic antidepressant treatment with classical and atypical antidepressant drugs and ECT leads to complex changes in the central adrenergic system, consisting of upregulation of alpha 1 and downregulation of alpha 2 and beta adrenoceptors. These changes may lead to a specific facilitation of neurotransmission in structures employing alpha 1 adrenoceptors, involved in the control of mood and emotions.
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