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  • Title: A murine model of polymyositis induced by coxsackievirus B1 (Tucson strain).
    Author: Strongwater SL, Dorovini-Zis K, Ball RD, Schnitzer TJ.
    Journal: Arthritis Rheum; 1984 Apr; 27(4):433-42. PubMed ID: 6324823.
    Abstract:
    A murine model of polymyositis induced by coxsackievirus B1, Tucson strain (CVBT) is described. Intraperitoneal CVBT inoculation of CD 1 Swiss mice less than 48 hours old resulted in proximal hindquarter weakness that was first apparent 7 days after viral challenge and persisted for more than 10 weeks. Electromyographic and histologic evidence of a continuing myositis was present during this entire period of time. However, virus was not detectable later than 2 weeks post infection, despite clinical progression of disease. The finding of electromyographic and histologic abnormalities in CVBT-infected mice, long after virus had cleared and neutralizing antibody production evoked, suggests that persistent myositis may be immunologically mediated, triggered by the initial acute viral infection.
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