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  • Title: [Molecular polarity dependence of the transformed steroid effect on Na,K-ATPase].
    Author: Kamernitskiĭ AV, Reshetova IG, Mirsalikhova NM, Levi VG, Chernoburova EI.
    Journal: Biokhimiia; 1984 Feb; 49(2):316-20. PubMed ID: 6324892.
    Abstract:
    The transformed steroids containing an additional cycle E (delta-lactone or 16.23-pyranone) or 23-carbethoxy side chain (1.10(-5) M) inhibit Na,K-ATPase from pig kidney medulla. The steroid structure has a noticeable effect on ATPase inhibiton varying from 9 to 35%. The data obtained suggest that the position, stereochemistry and the uneven distribution of polar substituents in the steroid molecule are essential for ATPase inhibition by steroid aglycons.
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