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  • Title: Iodide organification defect in a cold thyroid nodule: absence of iodide effect on cyclic AMP accumulation.
    Author: Demeester-Mirkine N, Van Sande J, Dor P, Heimann R, Cochaux P, Dumont JE.
    Journal: Clin Endocrinol (Oxf); 1984 Apr; 20(4):473-9. PubMed ID: 6325051.
    Abstract:
    A follicular adenoma of the thyroid was 'hot' one hour after 99mTc pertechnetate administration, but 'cold' 24 h after 131I iodide administration. Incubation of the tissue in vitro demonstrated a defect in iodide binding to proteins that was abolished by addition of an H2O2 generating system. In this tissue iodide failed to inhibit TSH-induced cyclic AMP accumulation. The results show that iodide oxidation is required for its inhibitory action on cyclic AMP accumulation in human thyroid.
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