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  • Title: Immunity to challenge in volunteers vaccinated with an inactivated current or earlier strain of influenza A(H3N2).
    Author: Larson HE, Tyrrell DA, Bowker CH, Potter CW, Schild GC.
    Journal: J Hyg (Lond); 1978 Apr; 80(2):243-8. PubMed ID: 632564.
    Abstract:
    Volunteers were inoculated with vaccine made from the 30c mutant, A/Port Chalmers/73 or B/Hong Kong/8/73. Preliminary experiments showed that the 30 c strain was antigenically quite close to A/HK/8/68. Volunteers given 30c developed haemagglutination inhibiting antibodies against the 'current' 1973 serotypes (as well as to the vaccine virus) but the titres were less than those after the A/PC/73 vaccine. Volunteers were then challenged with a live attenuated virus, WRL 105, with A/Finland/4/74 antigens, by intranasal inoculation. The rates of infection were 43% after B/Hong Kong/8/73, 20% after 30c and 5% after A/PC/73. This indicated that the 30c gave some protection but that the vaccine prepared from the current strain gave more.
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