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  • Title: [Clinical effect of a cephalosporin derivative, cefotiam, on otorhinolaryngologic infections].
    Author: Baba S, Wada K, Hatano T, Kinoshita H, Sugimori H, Sasaki T, Miyano K, Maruyama H, Takimoto I, Inafuku S.
    Journal: Jpn J Antibiot; 1983 Oct; 36(10):2693-710. PubMed ID: 6325739.
    Abstract:
    CTM was administered at dose levels of 1 to 3 g a day to 77 cases of otorhinolaryngological infections, and the following results were obtained: The effect of the drug was determined in 75 cases. The responders were 3 out of 5 (60.0%) in acute suppurative otitis media, 4 out of 11 (36.4%) in chronic suppurative otitis media, 39 out of 43 (90.7%) in tonsillitis and peritonsillar abscess and 12 out of 16 (75.0%) in other diseases, a total of 58 out of 75 cases (77.3%). The bacteriological effect of CTM was evaluated in 53 cases, and bacterial eradication was demonstrated in 41 cases (77.4%). Also, its antibacterial potency was 2 to 4 times superior in comparison to that of CEZ against isolated bacteria in which MICs were measurable. Side effects which were neither severe nor specific were recognized in 3 out of 77 cases (3.9%). In the cases with abnormal laboratory values, none was determinable to be attributed to CTM.
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