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  • Title: [Cefotiam passage into the maxillary sinus tissues].
    Author: Nakashima M, Ikoma H, Yokoyama M, Suzuki T, Sugihara S.
    Journal: Jpn J Antibiot; 1983 Oct; 36(10):2730-2. PubMed ID: 6325743.
    Abstract:
    Clinical study was made on cefotiam (CTM) and the following results were obtained. Tissue concentrations of CTM were determined 1 hour after intravenous injection (CTM 1 g) in chronic sinusitis and maxillary cyst. Concentrations of CTM were 16.53 micrograms/g, 13.26 micrograms/g in mucosa of the maxillary sinus, maxillary cyst, respectively. Antibacterial activity of CTM was measured on Escherichia coli, Staphylococcus epidermidis, Aerococcus, Acidaminococcus fermentans, Peptostreptococcus anaerobius; that were isolated from pus of maxillary sinus. The highest MIC on them was 3.13 micrograms/ml.
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