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  • Title: Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.
    Author: Steffen D.
    Journal: Proc Natl Acad Sci U S A; 1984 Apr; 81(7):2097-101. PubMed ID: 6326104.
    Abstract:
    Sixty-one murine leukemia virus-induced lymphomas were examined for evidence of proviral insertions adjacent to known oncogenes. Five of these lymphomas were found to have alterations adjacent to c-myc. Two of the lymphomas with altered c-myc sequences were examined in detail. Evidence was obtained showing that the alterations in the c-myc sequences in these two lymphomas were the result of proviral integrations. This result suggests that lymphomagenesis by murine leukemia viruses can result from insertional mutagenesis of cellular oncogenes.
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