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  • Title: Conditions favoring immunological enhancement of a murine allogeneic lymphoma.
    Author: Rumi L, Colmerauer ME, Pasqualini CD.
    Journal: Arch Geschwulstforsch; 1976; 46(6):457-60. PubMed ID: 63273.
    Abstract:
    An in vivo model was used which permits the growth of AKR lymphoma allografts inoculated within a glass cylinder subcutaneously implanted in BALB mice. Pretreatment of the host with acellular tumor extracts or tumor cells enclosed within a diffusion chamber significantly increased tumor incidence. On the contrary, donor spleen extracts did not alter tumor incidence while viable spleen cells within a diffusion chamber even prevented tumor development. It can be concluded that in this model a condition of maximal tumor enhancement can be attained with soluble tumor antigen but not with normal spleen extracts.
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