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  • Title: Electrophysiological properties of macrophages.
    Author: Gallin EK.
    Journal: Fed Proc; 1984 Jun; 43(9):2385-9. PubMed ID: 6327398.
    Abstract:
    Electrophysiological studies indicate that the macrophage can display at least two different K conductances, a Ca-mediated K conductance and an inward rectifying K conductance, as well as an electrogenic Na+-K+ pump. Spontaneous hyperpolarizations associated with a Ca-mediated K permeability have been noted in all types of macrophages studied. Similar membrane hyperpolarizations can be elicited by a variety of stimuli that presumably increase intracellular calcium. These include mechanical and electrical stimulation as well as exposure to endotoxin-activated serum, chemotactic peptides, and the Ca ionophore A23187. Recent patch clamp studies on macrophages demonstrated channel activity that probably corresponds to currents through the inward rectifying K conductance previously described with current clamp techniques. With the advent of the patch clamp, this and other conductances can be effectively examined by using both whole-cell voltage clamp and patch recordings in a variety of different macrophages, including small freshly isolated cells.
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