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  • Title: Report of a case of pheochromocytoma producing immunoreactive ACTH and beta-endorphin.
    Author: Schroeder JO, Asa SL, Kovacs K, Killinger D, Hadley GL, Volpé R.
    Journal: J Endocrinol Invest; 1984 Apr; 7(2):117-21. PubMed ID: 6327797.
    Abstract:
    A 47-year old woman is presented who had a left adrenal pheochromocytoma with manifestations also indicative of ectopic ACTH syndrome. The excised adrenal gland showed both an adrenal medullary tumor and adrenal cortical hyperplasia. Immunostaining also showed the presence in the tumor of ACTH and beta endorphins. The immediate post-adrenalectomy decline of catecholamines, ACTH, cortisol and beta endorphins indicate that the adrenal itself was the source of these hormones. This patient, the thirteenth now reported in the literature, represents one form of ectopic ACTH syndrome in which the lesion is benign, and in which a successful outcome can be anticipated.
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