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  • Title: Naltrexone prevents footshock-induced performance deficit in rats.
    Author: McCubbin JA, Kizer JS, Lipton MA.
    Journal: Life Sci; 1984 May 21; 34(21):2057-66. PubMed ID: 6328153.
    Abstract:
    Three experiments demonstrate that inescapable footshock delivered to unrestrained rats produces analgesia as well as performance deficits in subsequent one-way shuttle acquisition. Both the performance and the antinociceptive effects are prevented by pretreatment with as little as 0.1 mg/kg i.p. of the opiate antagonist, naltrexone. These studies suggest that both effects are mediated through opiate receptors with similar underlying naltrexone pharmaco-dynamics.
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