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  • Title: Oxytocin potentiates the ACTH-releasing activity of CRF(41) but not vasopressin.
    Author: Gibbs DM, Vale W, Rivier J, Yen SS.
    Journal: Life Sci; 1984 Jun 04; 34(23):2245-9. PubMed ID: 6328161.
    Abstract:
    The effects of CRF(41), oxytocin (OT), and arginine vasopressin (AVP) on ACTH secretion were studied alone and in combination in an in vitro system of superfused rat hemipituitaries. CRF(41) (10(-9)M) and AVP (10(-8)M) alone produced a significant increase in ACTH secretion while OT (10(-8)M) alone had no effect. However the same concentration of OT markedly potentiated the ACTH response to CRF(41) while having no effect on the ACTH response to AVP. The data support a physiologic role for OT in the regulation of ACTH secretion.
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