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  • Title: Transforming potential of a human protooncogene (c-fps/fes) locus.
    Author: Sodroski JG, Goh WC, Haseltine WA.
    Journal: Proc Natl Acad Sci U S A; 1984 May; 81(10):3039-43. PubMed ID: 6328490.
    Abstract:
    The protooncogene c-fps/fes is a single vertebrate locus homologous to both the fps transforming gene of Fujinami avian sarcoma virus and the fes transforming gene of two feline sarcoma virus isolates. The human c-fps/fes locus has been previously cloned and characterized. We report that a recombinant gene in which 3' human c-fps/fes sequences replace over 80% of the feline sarcoma virus fes sequences transforms NIH 3T3 mouse fibroblasts and encodes a protein kinase. Cells transformed by this recombinant possess increased phosphotyrosine levels. These observations demonstrate that a large carboxyl portion of a human c-fps/fes protein product can functionally complement a retroviral transforming protein.
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