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  • Title: Effects of the stilbene derivatives SITS and DIDS on intestinal ATPase activities.
    Author: Faelli A, Tosco M, Orsenigo MN, Esposito G.
    Journal: Pharmacol Res Commun; 1984 Apr; 16(4):339-50. PubMed ID: 6328545.
    Abstract:
    4-Acetamido-4'-isothiocyano-2,2'-disulfonic stilbene (SITS) and 4,4'-diisothiocyano-2,2'-disulfonic stilbene (DIDS) effects have been tested both in the basolateral membranes (BLMs) of jejunum enterocytes and in the same intestinal tract, everted and incubated "in vitro". Total and (Na,K)-ATPase activities of BLMs are inhibited in a similar way by the two disulfonic stilbenes as well as the fluid transintestinal transport in the everted intestine; on the contrary cell Na and K are unaffected. SITS and DIDS inhibition of (Na,K)-ATPase seems to take place at the cytoplasmic side of the BLM.
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