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  • Title: The effect of beta-(Tyr9)melanotropin-(9-18) on the active avoidance and open-field behavior on rats pretreated with atropine or propranolol.
    Author: Vécsei L, Bollók I, Telegdy G, Coy DH, Schally AV.
    Journal: Pharmacol Res Commun; 1984 Apr; 16(4):369-79. PubMed ID: 6328547.
    Abstract:
    beta-(Tyr9)melanotropin-(9-18) inhibited the extinction of active avoidance behavior. The muscarinic cholinergic blocker atropine did not influence the peptide-induced inhibition, whereas the beta-receptor blocker propranolol decreased it. Furthermore, the peptide increased the ambulation of the animals. Neither the muscarinic blocker nor the beta-blocker had any action on this effect of beta-(Tyr9)melanotropin-(9-18). Atropine markedly decreased the defecation of the animals, and this effect was not influenced by the peptide. The results suggest that the beta-receptors play an important role in the inhibition of extinction induced by the peptide, however, the actions on the open-field activity are mediated by different mechanisms.
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