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  • Title: Action of the e locus of mice in the response of phaeomelanic hair follicles to alpha-melanocyte-stimulating hormone in vitro.
    Author: Tamate HB, Takeuchi T.
    Journal: Science; 1984 Jun 15; 224(4654):1241-2. PubMed ID: 6328651.
    Abstract:
    Dibutyryl adenosine 3',5'-monophosphate (dibutyryl cyclic AMP) induced eumelanin synthesis in hair bulb melanocytes of recessive yellow (e/e) mice in vitro, whereas alpha-melanocyte-stimulating hormone (alpha-MSH) did not. In contrast, the melanocytes of lethal yellow (Ay/a) mice produced eumelanin in response to both dibutyryl cyclic AMP and alpha-MSH. These results suggest that the e locus controls a mechanism that determines the function of an alpha-MSH receptor.
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