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  • Title: Inhibition of ADP-ribosyltransferase activity of cholera toxin by MDL 12330A and chlorpromazine.
    Author: Bitonti AJ.
    Journal: Biochem Biophys Res Commun; 1984 Apr 30; 120(2):700-6. PubMed ID: 6329180.
    Abstract:
    ADP-ribosylation by cholera toxin of the guanine nucleotide binding regulatory protein (Gs) of rat liver membrane adenylate cyclase was inhibited by 0.1-1 mM MDL 12330A or 0.1-1 mM chlorpromazine. Basal as well as cholera toxin activated adenylate cyclase activity in liver membranes was also inhibited by the two drugs. NAD glycohydrolase activity and self-ADP-ribosylation of cholera toxin were also inhibited by MDL 12330A and chlorpromazine. These effects of MDL 12330A and chlorpromazine may be related to their effects on cholera toxin-induced fluid secretion in vivo.
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