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  • Title: Preparation of neurotensin selectively iodinated on the tyrosine 3 residue. Biological activity and binding properties on mammalian neurotensin receptors.
    Author: Sadoul JL, Mazella J, Amar S, Kitabgi P, Vincent JP.
    Journal: Biochem Biophys Res Commun; 1984 May 16; 120(3):812-9. PubMed ID: 6329185.
    Abstract:
    [Monoiodo- Tyr3 ]neurotensin, a neurotensin analogue that contains a single iodine atom on the side chain of Tyr 3 was prepared and purified. This analogue can be labeled at any specific radioactivity between 0 and 2000 Ci/mmol; its binding and biological properties on rat and guinea pig neurotensin receptors are identical to those of the parent peptide. These properties make [monoiodo- Tyr3 ]neurotensin the best suitable radioligand for detection and characterization of neurotensin receptors in various tissues and species.
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