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  • Title: Characterization of tin-technetium colloid in technetium-labeled albumin preparations.
    Author: Petit WA, DeLand FH, Pepper GH, Blanton L.
    Journal: J Nucl Med; 1978 Apr; 19(4):387-92. PubMed ID: 632927.
    Abstract:
    The Tc-99m human serum albumin (HSA) system has been reinvestigated with gel filtration as the assay method. Other than Tc-99m HSA, two radioactive components have been isolated by this technique. Both components are tin-technetium colloids of differing particle sizes, and the relative quantity of each one is pH-dependent. The colloid has been further characterized by protein-induced x-ray emission analysis (PIXE) and by tissue distribution in rats. By this gel-filtration method, commercial Tc-99m HSA kits have been evaluated and have revealed varying amounts of colloids present.
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