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  • Title: Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve.
    Author: Charpak S, Armstrong WE, Mühlethaler M, Dreifuss JJ.
    Journal: Brain Res; 1984 May 21; 300(1):83-9. PubMed ID: 6329430.
    Abstract:
    Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner. The remaining cells were unaffected. The stimulatory effect of oxytocin was reversibly antagonized by a synthetic structural analogue known to block the peripheral, endocrine effects of neurohypophysial peptides. A selective oxytocic agonist was as potent as oxytocin, whereas vasopressin exerted a much weaker effect. We therefore suggest that neurones located in DMX are endowed with receptors for oxytocin.
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