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  • Title: Naloxone blocks the analgesic action of levorphanol but not of dextrorphan in the leopard frog.
    Author: Stevens CW, Pezalla PD.
    Journal: Brain Res; 1984 May 28; 301(1):171-4. PubMed ID: 6329442.
    Abstract:
    Intraspinal injection of levorphanol (3 micrograms) at the lumbar area of the leopard frog, Rana pipiens, induced analgesia which was completely blocked by co-injection of naloxone (3 micrograms), whereas dextrorphan (3 micrograms) induced analgesia which was unaffected by naloxone. Subcutaneous levorphanol (20 or 80 mg/kg) induced a dose-dependent analgesia which was blocked by concurrent naloxone (2 mg/kg), while only the higher dose of dextrorphan (80 mg/kg) induced analgesia which was unaffected by concurrent naloxone at 8 or 80 mg/kg. These data are the first to indicate naloxone-insensitive, dextrorphan-induced analgesia.
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