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  • Title: [Concentration of cefotiam in the human prostatic tissue and bladder wall].
    Author: Koshido Y, Takara M, Kamiryo Y, Yamamoto N, Yasui H, Kojya T, Fujii M, Hashimoto O, Shimizu Y, Jyoko K.
    Journal: Jpn J Antibiot; 1984 Feb; 37(2):229-36. PubMed ID: 6330392.
    Abstract:
    Cefotiam (CTM) was administered in 31 patients before surgery and the concentration of CTM in serum, extirpated prostatic tissue and bladder wall was measured. Additional studies on pharmacokinetic parameters were carried out. The maximum level of serum concentration, following 1 hour intravenous infusion of 1 g, was 54.0 micrograms/ml after 1 hour and T1/2 was 1.16 hours. The maximum level of prostatic tissue was 19.5 micrograms/g and of bladder wall was 29.9 micrograms/g after 1.2 hours and T1/2 was 1.14 hours for both. An appropriate administration method for single use of CTM in the patient of UTI was discussed and 1 hour infusion of 1 g CTM was suggested.
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