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  • Title: Metastatic islet cell tumor in von Hippel-Lindau disease.
    Author: Cornish D, Pont A, Minor D, Coombs JL, Bennington J.
    Journal: Am J Med; 1984 Jul; 77(1):147-50. PubMed ID: 6331159.
    Abstract:
    A 56-year-old woman with many unusual manifestations of von Hippel-Lindau syndrome is described. In addition to retinal hemangioblastomas, pheochromocytoma, renal cell carcinoma, and multiple organ cysts, she had a cerebellar astrocytoma, pancreatic exocrine insufficiency, diabetes mellitus, thyrotoxicosis, and a metastatic calcitonin-secreting islet cell carcinoma. This case report documents the first example of a metastatic islet cell tumor in a patient with von Hippel-Lindau disease. The possible relationship between this disorder, the other neurocutaneous syndromes, and the multiple endocrine neoplasia syndromes is discussed.
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