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  • Title: The effects of anions on phosphoglycerate mutase.
    Author: Rose ZB, Kaklij GS.
    Journal: Biochem Biophys Res Commun; 1984 Jun 29; 121(3):834-41. PubMed ID: 6331429.
    Abstract:
    Chloride (5-100 mM) can activate the phosphoglycerate mutase reaction (3-PG in equilibrium with 2-PG). I-, N0-3, or higher Cl- inhibit the mutase reaction while allowing mixing of isotope from [32P]3-PG into a large pool of 2,3-bisphosphoglycerate. p-Hydroxybenzoate inhibits without causing isotope dilution. A number of anions (p-hydroxybenzoate approximate equal to NO3- greater than Cl- greater than Tes greater than acetate) stimulate the P-glycolate activated 2,3-bisphosphoglycerate phosphatase reaction of this enzyme. The same anions inhibit competitively with P-glycolate. A kinetic analysis relates the anion effects to changes in rates of association and dissociation of substrates.
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