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  • Title: Scanning electron microscopy in the diagnosis of bronchogenic squamous cell and small cell anaplastic carcinoma.
    Author: Tosi P, Luzi P, Leoncini L, Sforza V, Gotti G, Grossi A.
    Journal: Appl Pathol; 1983; 1(2):82-8. PubMed ID: 6331475.
    Abstract:
    The authors believe that differential diagnostic aspects between poorly-differentiated squamous cell carcinoma (PDS) and small cell anaplastic carcinoma (SCA) may be shown by scanning electron microscopy (SEM) analysis of 'thick' sections from routine paraffin-embedded tissues. In 8 'sample' cases features were demonstrated which were typical of PDS (well-defined outlines of cells, intercellular bridges) and of SCA (fairly smooth cell surface, nuclei in relief, a spongy, granular-like appearance of cytoplasm).
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