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  • Title: [Carnosine protection of Ca2+ transport against damage induced by lipid peroxidation].
    Author: Dupin AM, Boldyrev AA, Arkhipenko IuV, Kagan VE.
    Journal: Biull Eksp Biol Med; 1984 Aug; 98(8):186-8. PubMed ID: 6331862.
    Abstract:
    The authors studied the protective action of carnosine on sarcoplasmic reticulum (SR) membranes from frog skeletal muscles destroyed by ascorbic acid-dependent lipid peroxidation (LPO). It was demonstrated that addition of carnosine to the incubation medium at a concentration of 25 mM sharply decelerated inactivation of Ca-ATPase of SR membranes, maintaining at the same time the coupling of hydrolysing and transport functions of the Ca-pump. When given at the same concentration carnosine inhibited the accumulation of LPO products reacting with 2-thiobarbituric acid. This effect of carnosine was followed by its utilization.
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