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  • Title: [Plasma retinol, beta-carotene and ascorbic acid levels and functional activity of lymphocytes in patients with large intestine cancer].
    Author: Sergeev AV.
    Journal: Vopr Pitan; 1984; (3):27-30. PubMed ID: 6332421.
    Abstract:
    The content of retinol and ascorbic acid in blood plasma and lymphocytes of colonic cancer patients was 2-3 times as reduced as compared to that in donors. The beta-carotene content in the patients' blood plasma did not show any statistical changes. The low content of vitamins A and C in the plasma correlated in the same patients with inhibition of the cell proliferative response to alloantigens in a mixed lymphocyte culture and with a reduction in the lymphocyte response to the T cell mitogen ConA. The proliferative activity of lymphocytes stimulated with the B cell mitogen PWM was lowered in patients insignificantly. The blood plasma retinol was measured by high-pressure liquid chromatography, with the use of C19-retinoid as an internal reference. The beta-carotene content was measured by a combination diffusion laser spectrometer, Mole-77.
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