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  • Title: [Clinico-immunological characteristics of schizophrenia patients based on neurocytotoxic test data].
    Author: Semenov SF, Vilkov GA, Siziakina LP, Kogan RD, Mogilina NP.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1984; 84(7):1069-73. PubMed ID: 6332442.
    Abstract:
    A clinico-immunological examination involved 39 patients with a prolonged unfavourable course of schizophrenia at the stage of disease exacerbation. Cytotoxic cerebral antibodies determined in the subcomissural organ-glomerular zone of the adrenal cortex model were found in 94.8% of those studied which was significantly higher than the amount of complement binding antibodies (59.0%). The cytotoxic action of sera was paralleled by the neurosensitization of T lymphocytes in the presence of their functional activity decrease. Many seropositive patients exhibited an increase in one, two or three classes of immunoglobulins which appears to confirm indirectly the correlation between the above phenomena. A comprehensive clinico-immunological examination of schizophrenic patients should facilitate a more profound insight into the pathogenesis of the disease and the selection of the appropriate therapy.
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