These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Role of intracellular calcium stores in the generation of phasic component of K-contraction of the frog myocardium].
    Author: Mukumov MR, Khodorova AB, Khodorov BI.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1984 Jun; 70(6):833-7. PubMed ID: 6332746.
    Abstract:
    Treatment of the frog heart ventricle strip with 24 mM caffeine under condition of repetitive stimulation increases the amplitude of and decelerates relaxation of the phasic component of potassium contraction (100 mM KCl), as well as prevents the phasic component suppression due to 15-min application of Ca-channels blocking agent D-600 (4 X 10(-5) g/ml) or to a long-lasting (15-20 min) inactivity of the preparation. Adrenaline inhibits the phasic component and accelerates its relaxation. Ca++ ions which trigger the phasic component of the K-contraction seems to enter the myoplasm at the onset of membrane depolarization not from the sarcoplasmic reticulum but from some other pools, probably from the hypothetic voltage-dependent caffeine-insensitive submembrane Ca-stores.
    [Abstract] [Full Text] [Related] [New Search]