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  • Title: [The HLA system and Itsenko-Cushing disease].
    Author: Manishkina RP, Andrusenko AB, Donskov SI, Kalinin AP, Klinova EG.
    Journal: Ter Arkh; 1984; 56(8):133-5. PubMed ID: 6333733.
    Abstract:
    The determination of HLA antigens in 54 patients with Icenko-Cushing's disease demonstrated the high rate of AIO antigens (50.7%), B8 (27.3%) and B27 (26.2%) antigens. In the control group, the rate of the same antigens amounted to 17.8, 16.3 and 7.4%, respectively. Specific features were also revealed in the rate of individual HLA haplotypes. The rate of A X IO, B8; A X IO, B27 haplotypes occurring relatively rarely in normal subjects was high in patients with Icenko-Cushing's disease. The high rate of AIO, B8 and B27 antigens may attest to the high risk of the development of Icenko-Cushing's disease in subjects carrying these antigens.
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