These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Reduced PLD repair ability in glutathione synthetase deficient human fibroblasts after UV irradiation.
    Author: Deschavanne PJ, Chavaudra N, Debieu D, Malaise EP.
    Journal: Int J Radiat Biol Relat Stud Phys Chem Med; 1984 Oct; 46(4):375-82. PubMed ID: 6334050.
    Abstract:
    Using a human cell strain deficient in glutathione synthetase and a related control, the role of glutathione in repair mechanisms has been investigated. UV light has been used in order to avoid the interaction between thiols and free radicals. When potentially lethal damage repair is completed, deficient cells in plateau phase exhibit smaller surviving fractions than do control cells. The ratio of surviving fractions in control/deficient cells is about 2 for the same radiation dose. These results indicate that thiols and especially GSH are involved in repair mechanisms.
    [Abstract] [Full Text] [Related] [New Search]