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  • Title: Prenatal treatment of congenital adrenal hyperplasia resulting from 21-hydroxylase deficiency.
    Author: David M, Forest MG.
    Journal: J Pediatr; 1984 Nov; 105(5):799-803. PubMed ID: 6334149.
    Abstract:
    In an attempt to prevent in utero virilization of female fetuses with 21-hydroxylase deficiency, six mothers at risk were treated with either hydrocortisone (n = 1) or dexamethasone (n = 5) in early pregnancy. Treatment was continued to term in the two pregnancies in which the diagnosis of an affected female fetus was confirmed. In patient 1 (hydrocortisone treatment) fetal adrenal suppression was only partial but the external genitalia were only slightly abnormal. In patient 2 (dexamethasone treatment) fetal adrenal suppression was achieved and the external genitalia were normal at birth. These encouraging results open a new prospect for treating congenital adrenal hyperplasia in utero.
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