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  • Title: Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-10. Toxicity of metabolites of miocamycin: acute toxicity of Mb12 in mice.
    Author: Yokota M, Takeda U, Odaki M, Sasaki H, Kawaoto H, Itoh T, Koeda T.
    Journal: Jpn J Antibiot; 1984 Aug; 37(8):1546-8. PubMed ID: 6334180.
    Abstract:
    We evaluated acute toxicity and estimated LD50 values of Mb12, one of the main metabolites of MOM, in male and female mice after single oral administration. Observations were continued for 1 week after treatment. The LD50 values were calculated according to Litchfield-Wilcoxon's method. It is concluded that LD50 values of Mb12 were 5,750 mg/kg (4,914.5-6,727.5 mg/kg) in male mice and 4,950 mg/kg (4,194.9-5,841.0 mg/kg) in female mice, respectively.
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