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  • Title: [Perioperative cefamandole prevention in aortocoronary bypass operations: the course of serum levels in extracorporeal circulation].
    Author: Klepetko W, Georgopoulos A, Graninger W, Miholic J, Sandtner W.
    Journal: Langenbecks Arch Chir; 1984; 362(4):237-43. PubMed ID: 6334208.
    Abstract:
    Antibiotic prophylaxis with 2 g Cefamandole at induction of anaesthesia was performed in 12 male patients undergoing aortocoronary bypass surgery. Caused by hemodilution, there was a marked decrease of serum concentration at the beginning of extracorporeal circulation, from 110.96 +/- 40.29 mcg/ml to 70.89 +/- 34.65 mcg/ml within 10 min. During extracorporeal circulation, elimination was as fast as before and after perfusion. 240 min after application, mean serum concentrations of 16.80 +/- 9.32 mcg/ml were measured. Failure of antibiotic prophylaxis in operations exceeding 4 h might be due to unadaequate antibiotic concentrations, beyond the minimal inhibitory concentration for the pathogens, reported to cause infections after cardiac operations.
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