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  • Title: Relationship between beta-lactamases production and resistance to beta-lactam antibiotics in clinical isolates of Enterobacteriaceae.
    Author: Romero E, Pagani L, Perduca M, Mignatti P, Malfa S, Mills V.
    Journal: Microbiologica; 1984 Jul; 7(3):209-18. PubMed ID: 6334220.
    Abstract:
    288 clinical isolates of Enterobacteriaceae were assayed for beta-lactamase production in order to assess the role played by beta-lactamases in resistance to beta-lactam antibiotics. The data obtained showed that beta-lactamase production is undoubtedly a fundamental determinant for resistance. In fact, there was a significant correlation between the specific activity of the enzyme and the MIC of the strains considered. However, the role played by permeability barriers and/or other factors should be stressed, especially in determining resistance to cephalosporins. The validity of the nitrocefin test for detection of beta-lactamase production in Enterobacteriaeae from clinical isolates was also investigated.
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