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  • Title: Coeliac disease: alpha-1-antitrypsin contents in jejunal mucosa before and after gluten-free diet.
    Author: Nielsen K.
    Journal: Histopathology; 1984 Sep; 8(5):759-64. PubMed ID: 6335124.
    Abstract:
    Biopsies of the jejunum from 10 patients suffering from coeliac disease were investigated by an immunohistochemical technique for alpha-I-antitrypsin. The biopsies obtained before treatment did not contain alpha-I-antitrypsin, but after a gluten-free diet alpha-I-antitrypsin was present in Paneth cells in the mucosal crypts. This finding suggests that the absence of alpha-I-antitrypsin in the jejunal mucosa might be a pathogenetic factor in coeliac disease.
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