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  • Title: Cyclosporin A inhibits the delayed-type hypersensitivity effector function of T lymphocytes without affecting their clonal expansion.
    Author: Milon G, Truffa-Bachi P, Shidani B, Marchal G.
    Journal: Ann Immunol (Paris); 1984; 135D(3):237-45. PubMed ID: 6335647.
    Abstract:
    The effect of an immunosuppressor, cyclosporin A (CsA), on the induction by sheep erythrocytes of T cells mediating the delayed-type hypersensitivity (DTH) reaction was investigated using a quantitative assay of DTH-mediating T lymphocytes. CsA administration did not affect their clonal expansion following immunization. The frequency of the DTH-mediating T cells was not significantly different in mice sensitized by antigens in the presence or absence of CsA. However, CsA interfered with expression of effector function of DTH-mediating T lymphocytes by impairing the production of pro-inflammatory factor(s). Resting T cells as well as blast T cells were sensitive to this inhibitory effect of CsA.
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