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  • Title: [N-acylated derivatives of cyclohexylaniline with potential antiallergic and analgesic-antiinflammatory activity].
    Author: de Meglio P, Ravenna F, Carenini G, Gentili P, Gabbiati GT, Riva M.
    Journal: Farmaco Sci; 1984 Dec; 39(12):1024-37. PubMed ID: 6335694.
    Abstract:
    Some N-acylated derivatives of cyclohexylaniline were prepared. These can be considered as derived from oxarbazol (A), a carbazolic structure with antiallergic activity, by breaking the bond between carbon atom 4a and 4b. In the new molecule the following groups were introduced: benzoic acid, salicylic acid, acetylsalicylic acid and tetrazol. The synthesized compounds were studied for analgesic, antiedema and antiallergic activity. Some showed analgesic action (phenylquinone) comparable with that of naproxen. Antiinflammatory activity was slight and antiallergic activity nonexistent.
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