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  • Title: Synthesis and pharmacological properties of N-arylpiperazine-N'-alkylindanes.
    Author: Misztal S, Chojnacka-Wójcik E, Bartyzel P, Moskal A, Tatarczyńska E, Wiczyńska B, Lewandowska A.
    Journal: Pol J Pharmacol Pharm; 1984; 36(6):697-703. PubMed ID: 6336001.
    Abstract:
    Ten new compounds, N-aryl substituted piperazinealkylindanes, have been synthesized. The most active one 1-(2-[4-(3-chlorophenyl)-1-piperazinyl]-ethyl)-indane (compound 9), displayed evident central serotoninolytic properties in the 5-hydroxytryptamine (5-HTP) head twitch test in mice, as well as in the tryptamine convulsions test and the quipazine-stimulated hind paw flexor reflex test in rats.
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