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Title: Regulation of the coagulant activity and surface binding of high molecular weight kininogen. Author: Colman RW, Silver LD, Purdon AD, Chang JJ, Scott CF. Journal: Trans Assoc Am Physicians; 1984; 97():113-23. PubMed ID: 6336014. Abstract: Cleavage of the procofactor, high molecular weight kininogen, by kallikrein, is required for expression of it cofactor activity. Coagulant activity associated with the light chain of high molecular weight kininogen is destroyed by proteolysis by factor XIa. The heavy chain of high molecular weight kininogen augments the binding of the light chain to activating surfaces without itself expressing coagulant activity.[Abstract] [Full Text] [Related] [New Search]