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  • Title: Genetic epidemiology of coeliac disease.
    Author: Tiwari JL, Betuel H, Gebuhrer L, Morton NE.
    Journal: Genet Epidemiol; 1984; 1(1):37-42. PubMed ID: 6336186.
    Abstract:
    Segregation analysis favors a gene additive on liability with a frequency of 0.022, which is nearly recessive on the penetrance scale. Less than one-eighth of DR3 and DR7 haplotypes carry a determinant for coeliac disease. There is significant excess of DR3/7 heterozygotes among patients, indicating that the determinants are qualitatively different in DR3 and DR7 haplotypes. Linkage to HLA is highly significant (maximum lod score = 10.9). Evidence for recombination of 8% in males is attributed to residual errors in the model. We suggest an approach to a more precise model.
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