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  • Title: [Variations of the delayed hypersensitivity reaction in mice inoculated with different lots of sheep red blood cells].
    Author: Giovanniello OA, Rondinone SN, Barrios HA, Armendariz MA, Nota NR.
    Journal: Rev Argent Microbiol; 1984; 16(2):97-100. PubMed ID: 6336362.
    Abstract:
    Delayed-type-hypersensitivity (DTH) response "in vivo" is commonly evaluated by the footpad swelling test (FPST). High doses of Sheep Red Blood Cells (SRBC) are known to produce negligible DTH, while low doses lead to optimal sensitization. As expected FPST values obtained in Balb/c mice using 10(6) or 10(8) SRBC as sensitizing doses, showed that in 9 out of 10 batches from individual rams, the former dose resulted in higher values than the latter. However, only 3 out of the above 9 exhibited statistically significant differences between immunizing doses (Table 1). Therefore, in our hands, the accuracy of FPST is highly dependent on the SRBC source. We suggest the need of testing individual SRBC batches at both dilutions before use.
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